Bromelain, a potent enzyme found in pineapples, has been used in traditional medicine for centuries to control autoimmune conditions and improve life. It has unique qualities, such as reducing inflammation and pain in rheumatoid arthritis, reducing gut inflammation in inflammatory bowel diseases like Crohn's disease and ulcerative colitis, and potentially addressing the underlying causes of allergy disorders. Bromelain is taken in through the digestive system and acts as an anti-inflammatory chemical, reducing inflammation and lowering inflammatory cytokines. It is often taken as a dietary supplement, with potential adverse effects. Recent research suggests that bromelain may help with autoimmune disorders, such as coeliac disease, inflammatory arthritis, and inflammatory bowel disease. However, its medical application is complex, and clinical trials are needed to determine its effectiveness, optimal dose, and long-term safety. Researchers are looking into bromelain, an enzyme found in pineapple, to see whether it could be used to treat autoimmune diseases. Bromelain can change how the immune system and inflammatory pathways work, which may lower inflammation and control how immune cells work. Studies show that eating pineapple with much bromelain or taking bromelain supplements could help people with rheumatoid arthritis and inflammatory bowel disease.