Formulation and in-vitro permeation kinetic studies of β-cyclodextrin complexed ketoconazole drug capped silver nanoparticles

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Original Article

Author Details : Bhargavi Kumaraswamy, Sunil S More*, Aneesa Fasim, BM Dinesh

Volume : 10, Issue : 2, Year : 2024

Article Page : 66-73

https://doi.org/10.18231/j.jpmhh.2024.016

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Abstract

Background: Invasive fungal infections are a growing global crisis due to environmental shifts and growing vulnerable populations. Pathogenic fungi that infect humans are developing resistance against all approved systemic antifungal drugs. Topical drug delivery systems provide a non-invasive way to distribute therapeutic substances directly to the site of action. Ketoconazole (KZ) is a BCS Class II broad-spectrum drug that is used to treat and prevent fungal infections in which Trichophyton rubrum is the main causative agent.

Materials and Methods: The present study utilizes an in-vitro model in which KZ is complexed with β-CD and then capped with AgNPs to formulate a cream and evaluated for the underlying mechanisms and amount of improved passive penetration. The formulated cream is characterized for physiochemical evaluation, Fourier transform infrared spectroscopy (FTIR), kinetic studies indicating the effective stability and encapsulation of the composite.

Results: The prepared sample was evaluated in terms of its appearance, drug content, spreadability, and viscosity. Drug diffusion through the dialysis membrane, and the findings showed the β-CD-KZ-AgNPs formulation had a significantly higher permeability than KZ alone and followed first-order kinetics with an anomalous release pattern. The higher solubility and stability of β-CD and nano-sized AgNPs resulted in improved penetration. This study investigates that β-CD-capped AgNPs can significantly enhance KZ passive penetration and diffusion, providing a potentially useful nanocarrier technology for antifungal treatment.

Conclusion: Enhancing the passive permeation and diffusion characteristics of KZ on β-Cyclodextrin (β-CD)-capped silver nanoparticles (AgNPs) presents a viable approach for enhancing drug delivery efficiency.

Keywords: Ketoconazole, Silver Nano particles, Beta-Cyclodextrin, Permeability, Diffusion

How to cite : Kumaraswamy B, More S S, Fasim A, Dinesh B, Formulation and in-vitro permeation kinetic studies of β-cyclodextrin complexed ketoconazole drug capped silver nanoparticles. J Prev Med Holist Health 2024;10(2):66-73

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